Computer scientist · Detroit, Michigan, USA

Trustworthy AI for
early medical diagnosis

I build explainable, calibrated methods for early diagnosis from medical images and clinical data, and release them as peer-reviewed papers and open tools for researchers and clinicians.

Medical diagnosis AI Open research tools Production AI engineering

M.S. Computer Science (GPA 3.93), Maharishi International University · Senior Full Stack Engineer, Volkswagen Group of America
mdrana.hossain@miu.edu · ranasl62@gmail.com

First authorKnee osteoporosis diagnosis · 31 citations
84 citationsh-index 5 · Google Scholar
Springer · IEEEPeer-reviewed publications
12 peer reviews3 Clarivate-verified
Open softwareEHR Risk Framework
VW GoAProduction RAG · agents

About

Making diagnostic AI more reliable, explainable, and reusable

Portrait of Md Rana Hossain
Md Rana Hossain · Detroit, Michigan

My research develops explainable deep-learning methods for early diagnosis from medical images and clinical data, and the reliability tools that make those models safer to evaluate: calibrated probabilities, leakage-aware validation, and risk-controlled deferral when a model is uncertain.

My first-author work covers multimodal imaging diagnosis for osteoporosis. I have co-authored Springer Nature and IEEE publications on heart disease, cancer, diabetic eye disease, Alzheimer’s disease, and gastrointestinal and brain imaging, and I serve as a peer reviewer for biomedical and AI-in-health venues.

I maintain the open-source EHR Risk Framework and wrote a methods book on early disease detection and clinical risk prediction. In industry, I deliver production LangChain/LangGraph retrieval and agent systems at Volkswagen Group of America.

Healthcare methods are research and education only—not a medical device and not bedside deployment.

Approach

Diagnosis research first

The work to be known for is explainable, calibrated diagnosis research and the open tools that carry it. Full-stack engineering is the supporting capacity used to build and release that software.

Research record

Peer-reviewed papers on medical diagnosis, peer review, and a methods book on early disease detection and clinical risk prediction.

Supporting engineering

Production LangChain/LangGraph retrieval and agent systems at Volkswagen Group of America, on dealer and technician platforms.

Where they meet

The research asks whether a model can be evaluated without leakage, with calibrated probabilities, and with an explanation of each prediction. The EHR Risk Framework is the open software for that evaluation loop on longitudinal risk modeling. It is built with ordinary production practice—FastAPI, Angular, a pytest suite, and GitHub Actions. It is not a medical device.

Research focus

Trustworthy diagnostic AI: explainable and calibrated

I am advancing AI methods that support earlier, more reliable diagnosis of high-burden diseases, and releasing the validation tools so that other U.S. laboratories, students, and public-health research partners can reuse them.

1. Diagnostic models

Explainable deep-learning and multimodal models for early diagnosis from medical images and clinical data, including osteoporosis, colorectal cancer, diabetic retinopathy, Alzheimer’s disease, gastrointestinal disease, brain tumor, and heart disease.

Examples: first-author knee osteoporosis framework; CRuSE-Heart (Springer).

2. A reliability layer

Calibrated probabilities, leakage-aware evaluation, and risk-controlled abstention, so a model can report how much to trust each prediction and defer when it should.

Examples: CRuSE-Heart risk-controlled selective ensembles; calibration and leakage audits in the EHR Risk Framework.

3. Open validation infrastructure

Free, citable, reproducible tools for external validation, calibration reporting, and explainability analysis, for university labs, nonprofit research groups, and students.

Example: EHR Risk Framework (MIT license, public documentation, live demo, Zenodo DOI).

Why this matters

  • Heart disease and cancer are the two leading causes of death in the United States, and Alzheimer disease is also among the ten leading causes (CDC NCHS FastStats, final 2024 data; NCHS Data Brief 548).
  • Published diagnostic-AI results are often inflated by data leakage, small single-source datasets, and uncalibrated probabilities. Clinicians and researchers need to know when a model can be trusted, not only how accurate it looked in one study.
  • Calibration and repeatable evaluation are how this work approaches two characteristics named in the NIST AI Risk Management Framework (AI RMF 1.0): valid and reliable, and explainable and interpretable. That is a research-method alignment only, not product certification.
  • Open methods and tools raise research capacity across many institutions, so the benefit does not stay inside one organization.

Roadmap

Planned work in the United States

Concrete next steps that build directly on completed work.

  1. Journal-level, externally validated diagnosis. Extend the first-author knee osteoporosis framework into a journal article with testing on additional public datasets.
  2. Reliability layer for imaging. Extend calibration and risk-controlled abstention from tabular and EHR settings to imaging classifiers, and report the results with external validation.
  3. First-author methods papers in preparation. A controlled audit of temporal leakage and inflated discrimination in EHR risk prediction, and calibrated probabilities with risk-controlled abstention.
  4. Open release and community use. Add imaging-focused modules, tutorials, and reproducibility benchmarks to the open framework, and seek collaborations with U.S. clinicians and research groups.

Collaboration inquiries from U.S. universities, clinicians, and research labs are welcome. Get in touch.

Scholarship

Publications

13 peer-reviewed publications and 1 book. Accepted, under-review, and in-preparation items are listed separately and are not included in that count. Author roles match publisher lists. Citation counts from Google Scholar (84 citations, h-index 5, checked 26 October 2026).

Medical diagnosis

Accepted and under review

In preparation — first author

Book and review article

Other computer-vision applications

Open software

Research tools released for reuse

EHR Risk Framework

Creator and maintainer. Open workbench for longitudinal risk modeling: index/horizon cohorts, patient-level splits, leakage audits, isotonic calibration (Brier, ECE), TreeSHAP, fairness slices, reproducible JSON manifests, FastAPI + Angular UI. Being extended toward imaging-diagnosis reliability analysis.

The citable archive is Zenodo version 1.0.0 (22 July 2026), which is also the version in CITATION.cff. The concept DOI always points at the latest version. The version DOI identifies that 1.0.0 record. The repository includes a pytest suite and a GitHub Actions workflow. GitHub showed 24 stars and 6 forks on 26 October 2026.

MIT License · research and education only · not clinical performance claims

Service

Peer review

Twelve completed reviews: 3 + 1 + 1 journal reviews and 1 + 1 + 1 + 4 conference reviews. The three Biomedical Physics & Engineering Express reviews are Web of Science (Clarivate) verified. Profile: WoS reviewer record.

Journals

  • Biomedical Physics & Engineering Express (IOP, ISSN 2057-1976) — 3 reviews, 1 paper, 2026 · Web of Science (Clarivate) verified · Vovoxjz4, fYL4oLXU, TYwFtCpm
  • PLOS ONE (ISSN 1932-6203) — 1 review, 1 paper, 2026 · manuscript PONE-D-26-29250 · journal-verified · k2QCAslj
  • International Journal of Public Health Practice and Promotion — 1 review, August 2026. Manuscript: Knowledge, Attitude, and Perception of Sickle Cell Disease Screening Among Adolescents in Bauchi North-Eastern Nigeria.

Conferences

  • 15th International Conference on Health Information Science (HIS 2026) — 1 completed review, August 2026, Microsoft CMT.
  • The International Conference on Artificial Intelligence in Health (aiHealth 2026), Mytilene, Lesvos, Greece — 1 review, July 27–29, 2026.
  • International Conference on Intelligent Systems and Smart Computing (ICISSC 2026), St. Claret College, Bangalore — 1 review, July 3–4, 2026.
  • AMIA 2027 Amplify Informatics Conference, American Medical Informatics Association — 4 completed reviews, 2026.

Training: Nature Masterclasses Focus on Peer Review; Elsevier Researcher Academy modules (2026). ResearcherID: PUC-9517-2026.

Industry

Professional experience

Production AI and full-stack delivery in the United States, showing the engineering capacity to ship reliable research software.

Senior Full Stack Engineer

Volkswagen Group of America · Auburn Hills, MI · Apr 2024 – present · Hybrid

  • Production LangChain / LangGraph RAG for repair-manual search with cited answers (Solr chunking and indexing) on dealer and technician platforms.
  • Multi-step agentic workflows (Infomedia, customer-feedback analysis); MCP tool wiring; LangSmith tracing and evaluation.
  • Spring Boot APIs and Angular 18 UI; led Angular 4→18 with NgRx; mentor engineers.
  • ELSA2Go / Infomedia on AWS; Connected Car, myVW+, SiriusXM, CARFAX integrations; CI/CD with Docker, GitHub Actions, Jenkins.

Java · Spring Boot · Angular · NgRx · Python · Solr · LangChain · LangGraph · MCP · LangSmith · Docker · AWS

Software Engineer & Director

The Tech Nerds Limited · Chattogram, Bangladesh · Oct 2021 – Jan 2023

  • Director-level delivery plus day-to-day engineering: monolith → microservices (Spring Boot, NestJS, React), JWT / Spring Security.
  • PostgreSQL/MySQL performance, dynamic form engine, CI/CD on Jenkins and AWS; Kafka, GraphQL, Kubernetes, Terraform.

Software Specialist, previously Associate

SSL Wireless · Dhaka, Bangladesh · FinTech / payments · May 2018 – Sep 2021

  • Specialist (2021): microservices split of high-traffic recharge (Spring Boot, Node.js, AWS); QR payments, Kafka, ELK, eKYC banking integrations.
  • Associate (2018–2020): Angular / Spring Boot payments and banking; legacy modernization.
  • Employee of the Month, December 2020.

Also built the open-source AGC Framework (agent governance and control library, published on Maven Central) and worked as an independent contractor on web and AI products.

Credentials

Education & professional standing

Education

M.S., Computer Science
Maharishi International University, Fairfield, IA
Feb 2023 – Oct 2025 · GPA 3.93/4.00

B.S., Computer Science and Engineering
Southeast University, Dhaka
2015 – 2019 · GPA 3.97/4.00 · First in class (batch topper)

Certifications

  • AWS Certified Solutions Architect – Associate (Credly)
  • Johns Hopkins / Coursera: The Social and Technical Context of Health Informatics
  • IBM / Coursera: Vector DBs for RAG; Build RAG Applications; Build AI Agents using MCP
  • Hugging Face: AI Agents Fundamentals

Memberships

  • IEEE — Professional Member
  • American Medical Informatics Association (AMIA)
  • American College of Artificial Intelligence and Medicine
  • HIMSS — Digital Member

Selected awards

  • First in class (batch topper), B.S. CSE, Southeast University
  • Employee of the Month, SSL Wireless (Dec 2020)
  • ACM ICPC Dhaka Site, Certificate of Achievement (2018)
  • National Collegiate Programming Contest, MBSTU (2017)

Contact

Get in touch